AMPH

Across TCGA patient cohorts, AMPH mutation is significantly associated with the RNA expression of many other genes, with 4,311 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AMPH-associated genes across cancer lineages are BIRC5, PATL1, and CDKN3. Each is linked with AMPH in more than 4 cancer types. Because this analysis shows association rather than direction, both AMPH-to-partner and partner-to-AMPH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BIRC5 grouped by AMPH-low versus AMPH-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AMPH→partner) and Y-score (partner→AMPH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	BIRC5 →	+0.477	+1.562	.005	.002	3	5
SKCM	PATL1 →	+0.567	+3.389	<.001	.004	3	4
LUAD	CDKN3 →	+0.761	+2.834	.007	.001	2	5
SKCM	GRPEL1 →	+0.364	+2.228	.005	.006	3	4
UCEC	MRPS15 →	+0.259	+1.820	.004	<.001	3	4
UCEC	POLE3 →	+0.355	+1.517	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,311 associations by consensus.

BIRC5 by AMPH expression — UCEC

Explore this box plot interactively →