AMPH

Across TCGA patient cohorts, AMPH mutation is significantly associated with the total protein of many other genes, with 79 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AMPH-associated genes across cancer lineages are eEF2, TFRC, and Caspase-7-cleavedD198. Each is linked with AMPH in more than 4 cancer types. Because this analysis shows association rather than direction, both AMPH-to-partner and partner-to-AMPH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by AMPH-low versus AMPH-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AMPH→partner) and Y-score (partner→AMPH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	eEF2 →	+0.293	+2.593	.018	.006	3	5
SKCM	TFRC →	+1.003	+3.000	<.001	.034	3	5
UCEC	Caspase-7-cleavedD198 →	+0.563	+1.550	<.001	.002	3	5
UCEC	Caveolin-1 →	-0.420	-1.906	.033	.014	3	4
UCEC	Cyclin-B1 →	+0.574	+1.584	<.001	<.001	3	4
SKCM	PAI-1 →	+1.153	+2.824	<.001	.034	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 79 associations by consensus.

eEF2 by AMPH expression — COAD

Explore this box plot interactively →