AMPD3

Across TCGA patient cohorts, AMPD3 mutation is significantly associated with the total protein of many other genes, with 57 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AMPD3-associated genes across cancer lineages are EGFR_pY1068, eIF4E, and FoxM1. Each is linked with AMPD3 in more than 2 cancer types. Because this analysis shows association rather than direction, both AMPD3-to-partner and partner-to-AMPD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by AMPD3-low versus AMPD3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AMPD3→partner) and Y-score (partner→AMPD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.211	-1.514	.013	.015	3	2
COAD	eIF4E →	+0.298	+2.820	<.001	.035	3	2
UCEC	FoxM1 →	+0.227	+1.807	.010	.004	3	2
UCEC	ACC1 →	+0.279	+2.183	.024	.033	3	2
UCEC	Akt_pT308 →	+0.430	+2.000	.045	.029	3	2
UCEC	Rad50 →	-0.233	-2.571	.004	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 57 associations by consensus.

EGFR_pY1068 by AMPD3 expression — UCEC

Explore this box plot interactively →