AMPD3

Across TCGA cell cohorts, AMPD3 mutation is significantly associated with the RNA expression of many other genes, with 600 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible AMPD3-associated genes across cancer lineages are AWAT2, KRTAP2-4, and OOSP4A. Each is linked with AMPD3 in more than 1 cancer types. Because this analysis shows association rather than direction, both AMPD3-to-partner and partner-to-AMPD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AWAT2 grouped by AMPD3-low versus AMPD3-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AMPD3→partner) and Y-score (partner→AMPD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	AWAT2 →	+0.016	+4.643	<.001	.008	3	2
SOFT_TISSUE	KRTAP2-4 →	+0.122	+4.930	<.001	.008	3	1
SOFT_TISSUE	OOSP4A →	+0.067	+4.930	<.001	.008	3	1
LUNG_NSCLC_LUSC	KCNK16 →	+0.413	+4.643	.001	.008	3	1
BLOOD_Leukemia	PPIL2 →	+0.609	+3.199	<.001	.007	3	1
BLOOD_Leukemia	HRH3 →	+0.026	+4.115	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 600 associations by consensus.

AWAT2 by AMPD3 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →