AMPD2

Across TCGA patient cohorts, AMPD2 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,168 significant associations in total. PRAD shows the largest number of these associations.

The most reproducible AMPD2-associated GO terms across cancer lineages are Regulation of cilium assembly, Maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), and IMP biosynthetic process. Each is linked with AMPD2 in more than 27 cancer types. Because this analysis shows association rather than direction, both AMPD2-to-partner and partner-to-AMPD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of cilium assembly grouped by AMPD2-low versus AMPD2-high in DLBC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (AMPD2→partner) and Y-score (partner→AMPD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
DLBC	Regulation of cilium assembly →	+0.069	+0.744	<.001	<.001	3	28
DLBC	Maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.070	+0.571	.002	<.001	3	27
DLBC	IMP biosynthetic process →	+0.062	+0.422	<.001	<.001	3	27
DLBC	Positive regulation of cyclin-dependent protein serine/threonine kinase activity →	+0.083	+0.666	<.001	<.001	3	26
DLBC	Positive regulation of organelle assembly →	+0.059	+0.604	.001	<.001	2	27
DLBC	RNA secondary structure unwinding →	+0.065	+0.542	<.001	<.001	3	26

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,168 associations by consensus.

Regulation of cilium assembly by AMPD2 expression — DLBC

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