AMPD2

Across TCGA cell cohorts, AMPD2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,239 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible AMPD2-associated GO terms across cancer lineages are IMP salvage, IMP biosynthetic process, and Calcium-independent cell-matrix adhesion. Each is linked with AMPD2 in more than 17 cancer types. Because this analysis shows association rather than direction, both AMPD2-to-partner and partner-to-AMPD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IMP salvage grouped by AMPD2-low versus AMPD2-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (AMPD2→partner) and Y-score (partner→AMPD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	IMP salvage →	+0.253	+1.211	<.001	<.001	3	18
URINARY_TRACT	IMP biosynthetic process →	+0.214	+1.341	<.001	<.001	3	16
STOMACH	Calcium-independent cell-matrix adhesion →	+0.227	+1.317	<.001	<.001	3	16
BONE	Protection from non-homologous end joining at telomere →	+0.136	+0.951	.001	.002	3	14
BLOOD_Lymphoma	Transcription initiation at RNA polymerase I promoter →	+0.122	+0.967	<.001	<.001	3	14
SKIN	Microtubule nucleation →	+0.096	+1.205	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,239 associations by consensus.

IMP salvage by AMPD2 expression — LUNG_NSCLC_LUSC

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