AMPD2

Across TCGA cell cohorts, AMPD2 mutation is significantly associated with the RNA expression of many other genes, with 22 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AMPD2-associated genes across cancer lineages are OR2AJ1, SPEM3, and MYF5. Each is linked with AMPD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both AMPD2-to-partner and partner-to-AMPD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2AJ1 grouped by AMPD2-low versus AMPD2-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AMPD2→partner) and Y-score (partner→AMPD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR2AJ1 →	+0.019	+4.734	<.001	.002	3	2
LARGE_INTESTINE	SPEM3 →	+0.011	+3.084	<.001	.002	3	2
BLOOD_Myeloma	MYF5 →	+0.016	+4.807	<.001	.006	3	1
BLOOD_Myeloma	FABP12 →	+0.060	+4.807	<.001	.006	3	1
UPPER_AERODIGESTIVE_TRACT	KRTAP16-1 →	+0.006	+4.736	<.001	.009	3	1
LUNG_NSCLC_LUAD	SMCP →	+0.032	+4.947	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

OR2AJ1 by AMPD2 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →