AMPD2

Across TCGA cell cohorts, AMPD2 mutation is significantly associated with the mutation status of many other genes, with 2,875 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible AMPD2-associated genes across cancer lineages are SYMPK, IQGAP1, and AP3D1. Each is linked with AMPD2 in more than 4 cancer types. Because this analysis shows association rather than direction, both AMPD2-to-partner and partner-to-AMPD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SYMPK grouped by AMPD2-low versus AMPD2-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AMPD2→partner) and Y-score (partner→AMPD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SYMPK →	+3.977	+5.117	.001	.001	1	5
UPPER_AERODIGESTIVE_TRACT	IQGAP1 →	+5.392	+5.392	.004	.004	1	5
BLOOD_Leukemia	AP3D1 →	+3.145	+3.932	.004	.004	1	4
SKIN	SCARF1 →	+5.392	+4.824	.004	.004	1	4
UPPER_AERODIGESTIVE_TRACT	KDM6B →	+5.392	+5.392	.004	.004	1	4
BLOOD_Lymphoma	ARID1A →	+1.883	+3.065	.006	.006	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,875 associations by consensus.

SYMPK by AMPD2 expression — SKIN

Explore this box plot interactively →