AMPD1

Across TCGA patient cohorts, AMPD1 mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AMPD1-associated genes across cancer lineages are Caspase-7-cleavedD198, Gab2, and Notch1. Each is linked with AMPD1 in more than 2 cancer types. Because this analysis shows association rather than direction, both AMPD1-to-partner and partner-to-AMPD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by AMPD1-low versus AMPD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AMPD1→partner) and Y-score (partner→AMPD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.844	+2.682	<.001	<.001	3	3
UCEC	Gab2 →	+0.283	+1.652	.016	.006	3	2
UCEC	Notch1 →	+0.159	+2.335	<.001	.002	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.311	-1.584	.035	.034	3	2
UCEC	PDCD4 →	-0.459	-1.838	.003	.007	3	2
UCEC	Rad50 →	-0.198	-1.938	.013	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

Caspase-7-cleavedD198 by AMPD1 expression — UCEC

Explore this box plot interactively →