AMPD1

Across TCGA cell cohorts, AMPD1 mutation is significantly associated with the RNA expression of many other genes, with 35 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AMPD1-associated genes across cancer lineages are NAT8B, OR6Q1, and OR8B4. Each is linked with AMPD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both AMPD1-to-partner and partner-to-AMPD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NAT8B grouped by AMPD1-low versus AMPD1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AMPD1→partner) and Y-score (partner→AMPD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	NAT8B →	+0.068	+4.786	<.001	<.001	3	2
OVARY	OR6Q1 →	+0.015	+4.807	<.001	.003	3	2
CNS	OR8B4 →	+0.036	+4.772	<.001	.002	3	1
BLOOD_Leukemia	LGI1 →	+0.091	+4.539	<.001	.007	3	1
SKIN	SLC10A2 →	+0.002	+3.700	<.001	.009	3	1
LARGE_INTESTINE	CBY1 →	+0.720	+3.160	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

NAT8B by AMPD1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →