AMOTL2

Across TCGA patient cohorts, AMOTL2 protein abundance is significantly associated with the RNA expression of many other genes, with 10,895 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible AMOTL2-associated genes across cancer lineages are CAV1, ACADSB, and RHOJ. Each is linked with AMOTL2 in more than 3 cancer types. Because this analysis shows association rather than direction, both AMOTL2-to-partner and partner-to-AMOTL2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, AMOTL2 versus CAV1 in BRCA, with a Pearson correlation of 0.35.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AMOTL2→partner) and Y-score (partner→AMOTL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CAV1 →	+1.086	+0.501	.001	.003	3	4
LSCC	ACADSB →	-0.579	-0.307	.007	.001	3	4
UCEC	RHOJ →	+0.707	+0.349	.002	.005	3	3
LSCC	FLNC →	+0.997	+0.324	.002	<.001	3	3
UCEC	LRCH2 →	+0.715	+0.361	.003	.002	3	3
LSCC	MICAL2 →	+0.759	+0.340	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,895 associations by consensus.

AMOTL2 vs CAV1 — BRCA

Explore this scatter interactively →