AMOTL2

Across TCGA patient cohorts, AMOTL2 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AMOTL2-associated genes across cancer lineages are Rad50, eEF2, and JNK_pT183_Y185. Each is linked with AMOTL2 in more than 2 cancer types. Because this analysis shows association rather than direction, both AMOTL2-to-partner and partner-to-AMOTL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rad50 grouped by AMOTL2-low versus AMOTL2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AMOTL2→partner) and Y-score (partner→AMOTL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rad50 →	-0.168	-1.415	.025	.010	3	3
UCEC	eEF2 →	+0.294	+1.415	.008	.010	3	2
UCEC	JNK_pT183_Y185 →	-0.152	-1.502	.003	.027	3	2
UCEC	MSH6 →	-0.285	-1.807	.005	.024	3	2
UCEC	mTOR_pS2448 →	-0.106	-1.664	.021	.019	3	2
UCEC	PCNA →	+0.203	+1.652	.002	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

Rad50 by AMOTL2 expression — UCEC

Explore this box plot interactively →