AMOTL2

Across TCGA cell cohorts, AMOTL2 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,285 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AMOTL2-associated GO terms across cancer lineages are Hippo signaling, Regulation of hippo signaling, and Regulation of protein K48-linked ubiquitination. Each is linked with AMOTL2 in more than 14 cancer types. Because this analysis shows association rather than direction, both AMOTL2-to-partner and partner-to-AMOTL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Hippo signaling grouped by AMOTL2-low versus AMOTL2-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (AMOTL2→partner) and Y-score (partner→AMOTL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Hippo signaling →	+0.150	+3.015	<.001	<.001	3	15
STOMACH	Regulation of hippo signaling →	+0.098	+2.661	<.001	<.001	3	15
BONE	Regulation of protein K48-linked ubiquitination →	+0.159	+2.286	.001	.001	3	15
LUNG_SCLC	Regulation of fibroblast proliferation →	+0.103	+2.639	<.001	.001	3	15
BONE	Vesicle-mediated transport to the plasma membrane →	+0.084	+2.646	<.001	<.001	3	14
BONE	Negative regulation of Rho protein signal transduction →	+0.176	+2.470	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,285 associations by consensus.

Hippo signaling by AMOTL2 expression — BONE

Explore this box plot interactively →