AMOTL1

Across TCGA pan-cancer cohorts, AMOTL1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated AMOTL1 data layer compared with 23 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher AMOTL1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated AMOTL1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and CCRCC show a favorable association.

HNSC, CCRCC, and PDAC are the cancer types where AMOTL1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	All	0.817	0.521	.002	35	view →
CCRCC	DFS	Quartile	All	0.945	0.598	<.001	33	view →
PDAC	DFS	Median	III,IV	0.488	0.233	.012	9	view →
GBM	OS	Tertile	All	0.603	0.325	.026	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

AMOTL1–HNSC (OS)

Open the HNSC breakdown →