AMOTL1

Across TCGA patient cohorts, AMOTL1 mutation is significantly associated with the RNA expression of many other genes, with 2,295 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AMOTL1-associated genes across cancer lineages are TCF4-AS1, RN7SL266P, and ADAM33. Each is linked with AMOTL1 in more than 2 cancer types. Because this analysis shows association rather than direction, both AMOTL1-to-partner and partner-to-AMOTL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TCF4-AS1 grouped by AMOTL1-low versus AMOTL1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AMOTL1→partner) and Y-score (partner→AMOTL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	TCF4-AS1 →	+0.122	+4.163	<.001	.003	3	3
LGG	RN7SL266P →	+0.153	+5.135	<.001	.004	3	3
UCEC	ADAM33 →	-0.727	-2.532	<.001	.001	3	2
UCEC	NOCT →	+0.483	+1.651	<.001	.001	3	2
UCEC	NCAPD3 →	+0.420	+1.329	.002	.007	3	2
UCEC	SLC25A4 →	+0.408	+1.668	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,295 associations by consensus.

TCF4-AS1 by AMOTL1 expression — SKCM

Explore this box plot interactively →