AMOTL1

Across TCGA patient cohorts, AMOTL1 mutation is significantly associated with the total protein of many other genes, with 58 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AMOTL1-associated genes across cancer lineages are PCNA, EGFR_pY1068, and Acetyl-a-Tubulin-Lys40. Each is linked with AMOTL1 in more than 2 cancer types. Because this analysis shows association rather than direction, both AMOTL1-to-partner and partner-to-AMOTL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by AMOTL1-low versus AMOTL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AMOTL1→partner) and Y-score (partner→AMOTL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.246	+1.807	<.001	.003	3	3
UCEC	EGFR_pY1068 →	-0.264	-2.050	<.001	<.001	3	2
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.303	+1.512	.046	.017	3	2
UCEC	INPP4B →	-0.195	-1.847	.043	.007	3	2
UCEC	MSH2 →	-0.277	-2.476	<.001	.001	3	2
UCEC	mTOR_pS2448 →	-0.188	-4.074	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 58 associations by consensus.

PCNA by AMOTL1 expression — UCEC

Explore this box plot interactively →