AMOTL1

Across TCGA cell cohorts, AMOTL1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,843 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible AMOTL1-associated GO terms across cancer lineages are Establishment of cell polarity involved in ameboidal cell migration, Negative regulation of cilium assembly, and Establishment or maintenance of cell polarity. Each is linked with AMOTL1 in more than 14 cancer types. Because this analysis shows association rather than direction, both AMOTL1-to-partner and partner-to-AMOTL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Establishment of cell polarity involved in ameboidal cell migration grouped by AMOTL1-low versus AMOTL1-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (AMOTL1→partner) and Y-score (partner→AMOTL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	Establishment of cell polarity involved in ameboidal cell migration →	+1.363	+2.326	<.001	<.001	3	15
LUNG_SCLC	Negative regulation of cilium assembly →	+0.082	+2.357	.002	.001	3	12
STOMACH	Establishment or maintenance of cell polarity →	+0.088	+2.338	.001	.001	3	12
BREAST	Regulation of RNA polymerase II transcription preinitiation complex assembly →	+0.121	+1.471	<.001	.002	3	11
LARGE_INTESTINE	Regulation of anaphase-promoting complex-dependent catabolic process →	+0.131	+2.165	<.001	<.001	2	12
STOMACH	Negative regulation of syncytium formation by plasma membrane fusion →	+0.112	+2.119	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,843 associations by consensus.

Establishment of cell polarity involved in ameboidal cell migration by AMOTL1 expression — BLOOD_Myeloma

Explore this box plot interactively →