AMMECR1L

Across TCGA patient cohorts, AMMECR1L mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AMMECR1L-associated genes across cancer lineages are eEF2, EGFR_pY1068, and FoxM1. Each is linked with AMMECR1L in more than 1 cancer types. Because this analysis shows association rather than direction, both AMMECR1L-to-partner and partner-to-AMMECR1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by AMMECR1L-low versus AMMECR1L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AMMECR1L→partner) and Y-score (partner→AMMECR1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.292	+3.459	.011	.005	3	2
UCEC	EGFR_pY1068 →	-0.211	-1.459	.009	.012	3	2
UCEC	FoxM1 →	+0.180	+1.459	.032	.012	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.407	-1.807	.005	.025	3	2
UCEC	PCNA →	+0.222	+1.716	.001	.003	3	2
UCEC	Shc_pY317 →	-0.174	-2.222	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

eEF2 by AMMECR1L expression — UCEC

Explore this box plot interactively →