AMMECR1

Across TCGA cell cohorts, AMMECR1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,304 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible AMMECR1-associated GO terms across cancer lineages are Negative regulation of calcium ion transmembrane transporter activity, Positive regulation of telomerase RNA localization to Cajal body, and Nuclear export. Each is linked with AMMECR1 in more than 10 cancer types. Because this analysis shows association rather than direction, both AMMECR1-to-partner and partner-to-AMMECR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of calcium ion transmembrane transporter activity grouped by AMMECR1-low versus AMMECR1-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (AMMECR1→partner) and Y-score (partner→AMMECR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Negative regulation of calcium ion transmembrane transporter activity →	+0.125	+0.761	<.001	<.001	3	9
BLOOD_Lymphoma	Positive regulation of telomerase RNA localization to Cajal body →	+0.100	+0.969	<.001	.001	3	9
SKIN	Nuclear export →	+0.059	+0.738	.004	.001	3	9
BLOOD_Myeloma	Mitotic G2/M transition checkpoint →	+0.062	+1.017	<.001	<.001	3	9
UPPER_AERODIGESTIVE_TRACT	Cell cycle checkpoint signaling →	+0.067	+0.792	.004	.001	1	11
LUNG_NSCLC_LUSC	DNA damage checkpoint signaling →	+0.061	+1.538	.007	.002	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,304 associations by consensus.

Negative regulation of calcium ion transmembrane transporter activity by AMMECR1 expression — PANCREAS

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