Across TCGA pan-cancer cohorts, AMMECR1-IT1 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of AMMECR1-IT1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where AMMECR1-IT1 RNA is repressed in tumor relative to normal tissue. In most cancer types AMMECR1-IT1 is over-expressed in tumor, although a few such as THCA and KIRP show the opposite, repressed pattern.

THCA, BLCA, and KIRP are the cancer types where AMMECR1-IT1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in AMMECR1-IT1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	All	−0.080	<.001	5	view →
BLCA	Female	All	+0.127	.022	4	view →
KIRP	Female	All	−0.062	.039	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: AMMECR1-IT1 RNA expression & survival · all AMMECR1-IT1 data types