AMFR

Across TCGA patient cohorts, AMFR protein abundance is significantly associated with the RNA expression of many other genes, with 3,995 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible AMFR-associated genes across cancer lineages are GOT2, CHMP1A, and FBXL8. Each is linked with AMFR in more than 2 cancer types. Because this analysis shows association rather than direction, both AMFR-to-partner and partner-to-AMFR results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, AMFR versus GOT2 in LSCC, with a Pearson correlation of 0.42.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AMFR→partner) and Y-score (partner→AMFR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	GOT2 →	+0.622	+0.135	<.001	<.001	3	3
LUAD	CHMP1A →	+0.358	+0.236	<.001	<.001	3	3
LSCC	FBXL8 →	+0.447	+0.154	<.001	.002	3	3
LUAD	ATP6V0D1 →	+0.525	+0.298	<.001	<.001	3	3
LSCC	C16orf91 →	+0.423	+0.204	<.001	<.001	3	3
LSCC	COQ9 →	+0.450	+0.136	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,995 associations by consensus.

AMFR vs GOT2 — LSCC

Explore this scatter interactively →