AMFR

Across TCGA cell cohorts, AMFR mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AMFR-associated genes across cancer lineages are OLFM3, KCNK17, and MDGA2. Each is linked with AMFR in more than 1 cancer types. Because this analysis shows association rather than direction, both AMFR-to-partner and partner-to-AMFR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OLFM3 grouped by AMFR-low versus AMFR-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AMFR→partner) and Y-score (partner→AMFR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OLFM3 →	+0.979	+3.847	.004	.001	3	1
LARGE_INTESTINE	KCNK17 →	+0.075	+3.906	<.001	.002	3	1
LARGE_INTESTINE	MDGA2 →	+0.163	+2.817	<.001	.007	3	1
LARGE_INTESTINE	SRSF12 →	+0.365	+3.392	.002	.006	3	1
LARGE_INTESTINE	TUB →	+1.455	+3.374	<.001	.005	3	1
LARGE_INTESTINE	CPLX4 →	+0.033	+3.807	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

OLFM3 by AMFR expression — LARGE_INTESTINE

Explore this box plot interactively →