AMER3

Across TCGA patient cohorts, AMER3 mutation is significantly associated with the total protein of many other genes, with 66 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AMER3-associated genes across cancer lineages are MEK1, Caspase-7-cleavedD198, and PCNA. Each is linked with AMER3 in more than 2 cancer types. Because this analysis shows association rather than direction, both AMER3-to-partner and partner-to-AMER3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by AMER3-low versus AMER3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AMER3→partner) and Y-score (partner→AMER3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.425	+2.058	<.001	<.001	3	3
LUSC	Caspase-7-cleavedD198 →	+0.392	+1.678	.010	.019	3	3
UCEC	PCNA →	+0.219	+2.247	.001	.001	3	3
UCEC	ASNS →	+0.310	+1.289	.007	.023	3	3
UCEC	ATM →	-0.566	-2.378	<.001	<.001	3	3
UCEC	DJ-1 →	+0.135	+1.289	.011	.023	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 66 associations by consensus.

MEK1 by AMER3 expression — UCEC

Explore this box plot interactively →