AMER3

Across TCGA cell cohorts, AMER3 mutation is significantly associated with the RNA expression of many other genes, with 421 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AMER3-associated genes across cancer lineages are CTBS, KIF1C, and NRTN. Each is linked with AMER3 in more than 1 cancer types. Because this analysis shows association rather than direction, both AMER3-to-partner and partner-to-AMER3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CTBS grouped by AMER3-low versus AMER3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AMER3→partner) and Y-score (partner→AMER3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CTBS →	+0.832	+3.131	<.001	.008	3	2
LARGE_INTESTINE	KIF1C →	+0.793	+3.502	.002	.001	3	2
LARGE_INTESTINE	NRTN →	+1.024	+3.502	<.001	.001	3	2
LARGE_INTESTINE	TEX46 →	+0.104	+3.497	.008	.004	3	2
CNS	OR11H6 →	+0.015	+3.321	<.001	.003	3	2
STOMACH	DAZ2 →	+0.690	+3.263	.009	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 421 associations by consensus.

CTBS by AMER3 expression — LARGE_INTESTINE

Explore this box plot interactively →