AMER2

Across TCGA cell cohorts, AMER2 mutation is significantly associated with the RNA expression of many other genes, with 198 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AMER2-associated genes across cancer lineages are SCGB1C1, SAMM50, and CCDC113. Each is linked with AMER2 in more than 1 cancer types. Because this analysis shows association rather than direction, both AMER2-to-partner and partner-to-AMER2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SCGB1C1 grouped by AMER2-low versus AMER2-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AMER2→partner) and Y-score (partner→AMER2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	SCGB1C1 →	+0.201	+4.981	<.001	.008	3	1
LARGE_INTESTINE	SAMM50 →	+0.451	+3.064	.009	.009	3	1
LARGE_INTESTINE	CCDC113 →	+0.807	+2.451	.002	.009	3	1
LARGE_INTESTINE	PRSS54 →	+0.021	+2.345	.002	.007	3	1
LARGE_INTESTINE	C19orf44 →	+0.479	+2.451	.001	.009	3	1
LARGE_INTESTINE	MAPK8 →	+0.701	+2.537	.002	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 198 associations by consensus.

SCGB1C1 by AMER2 expression — CNS

Explore this box plot interactively →