Across TCGA patient cohorts, AMER1 mutation is significantly associated with the total protein of many other genes, with 68 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AMER1-associated genes across cancer lineages are PDCD4, MEK1, and PCNA. Each is linked with AMER1 in more than 3 cancer types. Because this analysis shows association rather than direction, both AMER1-to-partner and partner-to-AMER1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AMER1→partner) and Y-score (partner→AMER1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PDCD4 →	-0.860	-3.000	.005	.038	3	3
UCEC	MEK1 →	+0.262	+1.530	.005	.003	3	3
UCEC	PCNA →	+0.131	+1.044	.019	.014	3	3
UCEC	Cyclin-B1 →	+0.551	+1.788	<.001	<.001	3	3
COAD	p27 →	-0.204	-3.053	.001	<.001	3	2
LUAD	Rb_pS807_S811 →	+0.317	+2.459	.019	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 68 associations by consensus.

Exploration

AMER1 survival (RNA) · tumor vs normal (RNA) · all AMER1 data types