Across TCGA cell cohorts, AMER1 mutation is significantly associated with the RNA expression of many other genes, with 354 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AMER1-associated genes across cancer lineages are C1QBP, ELOA3DP, and ECI2. Each is linked with AMER1 in more than 1 cancer types. Because this analysis shows association rather than direction, both AMER1-to-partner and partner-to-AMER1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AMER1→partner) and Y-score (partner→AMER1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	C1QBP →	+0.756	+2.714	<.001	.002	3	2
LARGE_INTESTINE	ELOA3DP →	+0.018	+2.688	<.001	<.001	3	2
LARGE_INTESTINE	ECI2 →	+1.554	+3.169	<.001	.009	3	2
LARGE_INTESTINE	FAM153CP →	+0.257	+2.146	<.001	.007	3	2
LARGE_INTESTINE	THAP3 →	+0.614	+3.459	<.001	.001	3	2
OVARY	SOX1 →	+0.756	+3.187	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 354 associations by consensus.

Exploration

AMER1 survival (RNA) · tumor vs normal (RNA) · all AMER1 data types