AMELX

Across TCGA patient cohorts, AMELX mutation is significantly associated with the RNA expression of many other genes, with 605 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AMELX-associated genes across cancer lineages are DEF8, FAP, and OR2B7P. Each is linked with AMELX in more than 1 cancer types. Because this analysis shows association rather than direction, both AMELX-to-partner and partner-to-AMELX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEF8 grouped by AMELX-low versus AMELX-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AMELX→partner) and Y-score (partner→AMELX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DEF8 →	+0.447	+2.606	.005	.006	3	2
UCEC	FAP →	+0.974	+3.711	<.001	<.001	3	2
SKCM	OR2B7P →	+0.048	+2.421	.001	.003	3	1
SKCM	NOXO1 →	+0.024	+2.479	<.001	.002	3	1
SKCM	MIR103A1 →	+0.170	+3.343	<.001	.004	3	1
SKCM	RNA5SP507 →	+0.314	+2.245	.005	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 605 associations by consensus.

DEF8 by AMELX expression — UCEC

Explore this box plot interactively →