AMELX

Across TCGA patient cohorts, AMELX mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AMELX-associated genes across cancer lineages are Di-Ras3, ACC1, and p62 Lck ligand. Each is linked with AMELX in more than 1 cancer types. Because this analysis shows association rather than direction, both AMELX-to-partner and partner-to-AMELX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Di-Ras3 grouped by AMELX-low versus AMELX-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AMELX→partner) and Y-score (partner→AMELX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Di-Ras3 →	-0.184	-3.321	.018	.010	3	1
UCEC	ACC1 →	+0.544	+3.000	.004	.036	2	1
UCEC	p62 Lck ligand →	+0.549	+3.179	.001	.010	2	1
UCEC	4E-BP1 →	+0.422	+3.321	.002	.010	2	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

Di-Ras3 by AMELX expression — UCEC

Explore this box plot interactively →