AMELX

Across TCGA cell cohorts, AMELX RNA expression is significantly associated with the go_rna of many other GO terms, with 295 significant associations in total. STOMACH shows the largest number of these associations.

The most reproducible AMELX-associated GO terms across cancer lineages are Positive regulation of endocytosis, Response to X-ray, and Positive regulation of chondrocyte proliferation. Each is linked with AMELX in more than 2 cancer types. Because this analysis shows association rather than direction, both AMELX-to-partner and partner-to-AMELX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of endocytosis grouped by AMELX-low versus AMELX-high in CNS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (AMELX→partner) and Y-score (partner→AMELX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Positive regulation of endocytosis →	+0.061	+0.017	<.001	.007	3	3
STOMACH	Response to X-ray →	-0.106	-0.111	<.001	.002	3	2
LUNG_SCLC	Positive regulation of chondrocyte proliferation →	+0.167	+0.049	.003	.006	2	3
LUNG_SCLC	Negative regulation of ion transmembrane transporter activity →	-0.093	-0.044	.004	.005	3	2
STOMACH	Negative regulation of epithelial to mesenchymal transition →	+0.087	+0.103	.005	.006	3	2
STOMACH	Transposable element silencing by mRNA destabilization →	-0.138	-0.174	.008	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 295 associations by consensus.

Positive regulation of endocytosis by AMELX expression — CNS

Explore this box plot interactively →