AMDHD2

Across TCGA patient cohorts, AMDHD2 mutation is significantly associated with the RNA expression of many other genes, with 2,882 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AMDHD2-associated genes across cancer lineages are SSTR5, HSPA4L, and FUT10. Each is linked with AMDHD2 in more than 2 cancer types. Because this analysis shows association rather than direction, both AMDHD2-to-partner and partner-to-AMDHD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SSTR5 grouped by AMDHD2-low versus AMDHD2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AMDHD2→partner) and Y-score (partner→AMDHD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SSTR5 →	+0.500	+2.179	<.001	<.001	3	3
UCEC	HSPA4L →	+0.735	+3.332	<.001	.005	3	3
UCEC	FUT10 →	+0.412	+2.247	.003	.002	3	3
UCEC	H3P16 →	+1.031	+2.747	<.001	<.001	3	3
UCEC	PSMA4 →	+0.421	+2.769	.003	<.001	3	3
UCEC	PARP2 →	+0.413	+2.370	.004	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,882 associations by consensus.

SSTR5 by AMDHD2 expression — UCEC

Explore this box plot interactively →