AMDHD1

Across TCGA patient cohorts, AMDHD1 mutation is significantly associated with the RNA expression of many other genes, with 809 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AMDHD1-associated genes across cancer lineages are RNA5SP90, DPPA2P1, and AK6P1. Each is linked with AMDHD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both AMDHD1-to-partner and partner-to-AMDHD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP90 grouped by AMDHD1-low versus AMDHD1-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AMDHD1→partner) and Y-score (partner→AMDHD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RNA5SP90 →	+0.558	+4.204	.001	.004	3	2
LUSC	DPPA2P1 →	+0.107	+4.150	<.001	.003	3	2
SKCM	AK6P1 →	+0.052	+3.302	.001	.009	3	2
SKCM	RNA5SP248 →	+0.300	+3.045	<.001	.008	3	2
SCLC	DEFB135 →	+0.984	+5.624	<.001	.003	3	1
BLCA	RNY4P16 →	+0.485	+5.444	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 809 associations by consensus.

RNA5SP90 by AMDHD1 expression — LUSC

Explore this box plot interactively →