AMDHD1

Across TCGA cell cohorts, AMDHD1 mutation is significantly associated with the mutation status of many other genes, with 402 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible AMDHD1-associated genes across cancer lineages are CDC25B, STAG1, and FBXW2. Each is linked with AMDHD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both AMDHD1-to-partner and partner-to-AMDHD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDC25B grouped by AMDHD1-low versus AMDHD1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AMDHD1→partner) and Y-score (partner→AMDHD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CDC25B →	+4.321	+5.285	.005	.005	1	2
BLOOD_Leukemia	STAG1 →	+4.736	+5.560	.003	.003	1	2
BLOOD_Leukemia	FBXW2 →	+4.321	+5.285	.005	.005	1	2
BLOOD_Leukemia	HSDL2 →	+6.321	+6.321	.001	.001	1	2
BLOOD_Leukemia	VRTN →	+4.000	+5.050	.008	.008	1	2
BLOOD_Lymphoma	RFX1 →	+5.014	+5.584	.003	.003	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 402 associations by consensus.

CDC25B by AMDHD1 expression — BLOOD_Leukemia

Explore this box plot interactively →