AMD1

Across TCGA patient cohorts, AMD1 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AMD1-associated genes across cancer lineages are STAT5a, ERK2, and IGFBP2. Each is linked with AMD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both AMD1-to-partner and partner-to-AMD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT5a grouped by AMD1-low versus AMD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AMD1→partner) and Y-score (partner→AMD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT5a →	+0.423	+2.000	.018	.032	3	2
UCEC	ERK2 →	+0.266	+3.169	.002	.018	3	1
UCEC	IGFBP2 →	-0.801	-2.000	.006	.032	3	1
UCEC	ACVRL1 →	-0.159	-3.156	.009	.018	3	1
UCEC	MSH6 →	-0.495	-3.169	<.001	.018	3	1
UCEC	Myosin-IIa →	+0.246	+2.592	.004	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

STAT5a by AMD1 expression — UCEC

Explore this box plot interactively →