AMBRA1

Across TCGA pan-cancer cohorts, AMBRA1 Mutation is linked to patient survival in 9 of 34 cancer types, making it a survival-associated AMBRA1 data layer compared with 22 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher AMBRA1 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated AMBRA1 expression acts as an unfavorable survival marker, although some lineages such as GBM and UCEC show a favorable association.

HNSC, LUSC, and SCLC are the cancer types where AMBRA1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	II,III,IV	0.374	0.687	.002	45	view →
LUSC	OS	Median	III,IV	0.168	0.696	<.001	26	view →
SCLC	OS	Median	II,III,IV	0.082	0.648	<.001	24	view →
KIRP	OS	Median	All	0.216	0.904	<.001	15	view →
GBM	DFS	Median	All	1.000	0.204	.042	6	view →
COAD	DFS	Median	All	0.277	0.572	.013	6	view →
UCEC	DFS	Median	All	0.949	0.825	.013	6	view →
ESCA	DFS	Median	All	0.317	0.539	.026	3	view →
SKCM	OS	Median	II,III,IV	0.182	0.404	.046	2	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

AMBRA1–HNSC (DFS)

Open the HNSC breakdown →