AMBRA1

Across TCGA pan-cancer cohorts, AMBRA1 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated AMBRA1 data layer compared with 22 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher AMBRA1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated AMBRA1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

HNSC, LUAD, and PDAC are the cancer types where AMBRA1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	II,III,IV	1.000	0.845	.006	29	view →
LUAD	OS	Tertile	II,III,IV	1.000	0.443	.022	9	view →
PDAC	DFS	Median	III,IV	0.520	0.808	.046	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

AMBRA1–HNSC (DFS)

Open the HNSC breakdown →