AMBRA1

Across TCGA patient cohorts, AMBRA1 RNA expression is significantly associated with the protein abundance of many other proteins, with 7,177 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible AMBRA1-associated proteins across cancer lineages are CELF1, P4HB, and RPL26. Each is linked with AMBRA1 in more than 4 cancer types. Because this analysis shows association rather than direction, both AMBRA1-to-partner and partner-to-AMBRA1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, AMBRA1 versus CELF1 in LSCC, with a Pearson correlation of 0.39.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (AMBRA1→partner) and Y-score (partner→AMBRA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CELF1 →	+0.252	+0.299	<.001	.002	3	5
BRCA	P4HB →	-0.295	-0.519	<.001	<.001	3	4
OV	RPL26 →	-0.503	-0.597	<.001	<.001	3	4
LUAD	CRELD2 →	-0.445	-0.259	.008	.007	3	4
LSCC	QSER1_T1207 →	+0.641	+0.355	.002	.007	3	3
OV	CACNA2D1 →	+0.447	+0.584	.009	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,177 associations by consensus.

AMBRA1 vs CELF1 — LSCC

Explore this scatter interactively →