AMBRA1

Across TCGA patient cohorts, AMBRA1 protein abundance is significantly associated with the RNA expression of many other genes, with 3,037 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible AMBRA1-associated genes across cancer lineages are SLC5A6, ANO7, and TRIQK. Each is linked with AMBRA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both AMBRA1-to-partner and partner-to-AMBRA1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, AMBRA1 versus SLC5A6 in LSCC, with a Pearson correlation of 0.32.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AMBRA1→partner) and Y-score (partner→AMBRA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SLC5A6 →	+0.494	+0.169	.001	.002	3	2
OV	ANO7 →	+0.554	+0.472	.005	.001	3	2
OV	TRIQK →	-0.661	-0.395	.006	.002	3	2
HNSC	SYNE1 →	-0.599	-0.351	.001	<.001	3	2
COAD	CASK-AS1 →	-0.736	-0.458	<.001	.008	3	2
HNSC	LIMCH1 →	-1.015	-0.330	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,037 associations by consensus.

AMBRA1 vs SLC5A6 — LSCC

Explore this scatter interactively →