AMBRA1

Across TCGA patient cohorts, AMBRA1 mutation is significantly associated with the RNA expression of many other genes, with 6,241 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AMBRA1-associated genes across cancer lineages are GOT1, MPDU1, and COQ3. Each is linked with AMBRA1 in more than 3 cancer types. Because this analysis shows association rather than direction, both AMBRA1-to-partner and partner-to-AMBRA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GOT1 grouped by AMBRA1-low versus AMBRA1-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AMBRA1→partner) and Y-score (partner→AMBRA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	GOT1 →	+0.793	+3.321	<.001	.009	3	4
COAD	MPDU1 →	+0.502	+2.820	<.001	.001	3	4
COAD	COQ3 →	+0.481	+2.820	.004	.001	3	4
COAD	LRRC36 →	-0.924	-3.574	<.001	.002	3	4
UCEC	UHRF1 →	+0.846	+2.198	<.001	<.001	3	3
UCEC	CCDC89 →	-0.522	-1.362	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,241 associations by consensus.

GOT1 by AMBRA1 expression — STAD

Explore this box plot interactively →