AMBRA1

Across TCGA patient cohorts, AMBRA1 mutation is significantly associated with the total protein of many other genes, with 60 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AMBRA1-associated genes across cancer lineages are ASNS, PKC-delta_pS664, and Rad50. Each is linked with AMBRA1 in more than 4 cancer types. Because this analysis shows association rather than direction, both AMBRA1-to-partner and partner-to-AMBRA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by AMBRA1-low versus AMBRA1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AMBRA1→partner) and Y-score (partner→AMBRA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ASNS →	+0.418	+2.467	.015	.011	3	5
UCEC	PKC-delta_pS664 →	-0.123	-2.662	<.001	<.001	3	3
UCEC	Rad50 →	-0.150	-1.050	.024	.023	3	3
UCEC	Caspase-7-cleavedD198 →	+0.480	+1.847	.003	.007	3	3
UCEC	4E-BP1 →	+0.312	+3.247	<.001	<.001	3	3
STAD	c-Kit →	-0.358	-3.321	.016	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 60 associations by consensus.

ASNS by AMBRA1 expression — COAD

Explore this box plot interactively →