AMBRA1

Across TCGA cell cohorts, AMBRA1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,884 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible AMBRA1-associated GO terms across cancer lineages are Response to mitochondrial depolarisation, Positive regulation of T-helper 17 cell lineage commitment, and Cytosolic transport. Each is linked with AMBRA1 in more than 16 cancer types. Because this analysis shows association rather than direction, both AMBRA1-to-partner and partner-to-AMBRA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Response to mitochondrial depolarisation grouped by AMBRA1-low versus AMBRA1-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (AMBRA1→partner) and Y-score (partner→AMBRA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Response to mitochondrial depolarisation →	+0.133	+1.016	<.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	Positive regulation of T-helper 17 cell lineage commitment →	+0.221	+0.812	<.001	.003	3	16
OESOPHAGUS	Cytosolic transport →	+0.064	+1.019	<.001	<.001	3	15
LUNG_SCLC	Positive regulation of intracellular steroid hormone receptor signaling pathway →	+0.159	+0.493	.001	.009	3	15
BONE	Transcription pausing by RNA polymerase II →	+0.246	+1.117	<.001	<.001	3	14
CNS	Regulation of autophagosome maturation →	+0.100	+0.611	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,884 associations by consensus.

Response to mitochondrial depolarisation by AMBRA1 expression — OESOPHAGUS

Explore this box plot interactively →