AMBN

Across TCGA pan-cancer cohorts, AMBN Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated AMBN data layer compared with 16 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher AMBN Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated AMBN expression acts as an unfavorable survival marker, although some lineages such as SKCM show a favorable association.

KIRC, COAD, and LUSC are the cancer types where AMBN Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.133	0.805	<.001	42	view →
COAD	OS	Median	All	0.362	0.811	<.001	19	view →
LUSC	DFS	Median	All	0.378	0.800	.008	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
SKCM	DFS	Median	II,III,IV	0.855	0.680	.047	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

AMBN–KIRC (OS)

Open the KIRC breakdown →