AMBN

Across TCGA patient cohorts, AMBN mutation is significantly associated with the RNA expression of many other genes, with 1,182 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AMBN-associated genes across cancer lineages are MVD, TRAPPC2L, and DAPK3. Each is linked with AMBN in more than 1 cancer types. Because this analysis shows association rather than direction, both AMBN-to-partner and partner-to-AMBN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MVD grouped by AMBN-low versus AMBN-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AMBN→partner) and Y-score (partner→AMBN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MVD →	+0.484	+2.613	.005	.005	3	2
UCEC	TRAPPC2L →	+0.386	+2.158	.001	.009	3	2
SKCM	DAPK3 →	+0.566	+3.497	<.001	.002	3	2
UCEC	CTU2 →	+0.522	+2.065	<.001	.004	3	2
UCEC	FANCA →	+0.542	+2.721	<.001	.003	3	2
SKCM	VHLL →	+0.096	+1.930	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,182 associations by consensus.

MVD by AMBN expression — SKCM

Explore this box plot interactively →