AMBN

Across TCGA patient cohorts, AMBN mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AMBN-associated genes across cancer lineages are IGFBP2, Shc_pY317, and ATM. Each is linked with AMBN in more than 1 cancer types. Because this analysis shows association rather than direction, both AMBN-to-partner and partner-to-AMBN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGFBP2 grouped by AMBN-low versus AMBN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AMBN→partner) and Y-score (partner→AMBN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IGFBP2 →	-0.581	-2.321	.014	.033	3	2
UCEC	Shc_pY317 →	-0.119	-1.700	.032	.042	3	2
UCEC	ATM →	-0.525	-2.700	.001	.006	3	2
LUSC	HSP70 →	+0.619	+2.816	.018	.036	3	1
LUSC	Rictor_pT1135 →	+0.172	+2.816	.011	.036	3	1
SKCM	PKC-a_pS657 →	-0.380	-2.459	.040	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

IGFBP2 by AMBN expression — UCEC

Explore this box plot interactively →