AMBN

Across TCGA cell cohorts, AMBN mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible AMBN-associated genes across cancer lineages are UGT2B10, CD1C, and FGF3. Each is linked with AMBN in more than 1 cancer types. Because this analysis shows association rather than direction, both AMBN-to-partner and partner-to-AMBN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UGT2B10 grouped by AMBN-low versus AMBN-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AMBN→partner) and Y-score (partner→AMBN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	UGT2B10 →	+0.049	+5.321	<.001	.005	3	1
CNS	CD1C →	+0.025	+4.981	<.001	.008	3	1
CNS	FGF3 →	+0.043	+4.981	<.001	.008	3	1
SKIN	XCL2 →	+0.067	+3.347	<.001	.005	3	1
SKIN	TMEM95 →	+0.031	+3.977	<.001	.001	3	1
SKIN	CYP4F8 →	+0.021	+3.632	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

UGT2B10 by AMBN expression — CNS

Explore this box plot interactively →