AMACR

Across TCGA patient cohorts, AMACR protein abundance is significantly associated with the protein abundance of many other proteins, with 14,874 significant associations in total. GBM shows the largest number of these associations.

The most reproducible AMACR-associated proteins across cancer lineages are SCP2, FRG1, and GPATCH8. Each is linked with AMACR in more than 4 cancer types. Because this analysis shows association rather than direction, both AMACR-to-partner and partner-to-AMACR results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, AMACR versus SCP2 in BRCA, with a Pearson correlation of 0.48.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (AMACR→partner) and Y-score (partner→AMACR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SCP2 →	+0.406	+0.439	<.001	<.001	3	5
GBM	FRG1 →	-0.436	-0.287	<.001	<.001	3	5
BRCA	GPATCH8 →	-0.313	-0.610	<.001	<.001	3	5
GBM	SMC1A →	-0.381	-0.378	<.001	<.001	3	5
BRCA	DEK →	-0.470	-0.543	<.001	<.001	3	5
GBM	EXOSC8 →	-0.358	-0.367	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,874 associations by consensus.

AMACR vs SCP2 — BRCA

Explore this scatter interactively →