AMACR

Across TCGA patient cohorts, AMACR mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible AMACR-associated genes across cancer lineages are eIF4E, ERK2, and MEK1. Each is linked with AMACR in more than 1 cancer types. Because this analysis shows association rather than direction, both AMACR-to-partner and partner-to-AMACR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by AMACR-low versus AMACR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AMACR→partner) and Y-score (partner→AMACR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.183	+3.335	.031	.005	3	1
UCEC	ERK2 →	+0.199	+2.000	.010	.030	3	1
UCEC	MEK1 →	+0.312	+2.584	.034	.010	3	1
UCEC	mTOR_pS2448 →	-0.146	-2.446	.014	.018	3	1
UCEC	Notch1 →	+0.166	+2.013	.003	.016	3	1
UCEC	PCNA →	+0.280	+4.169	.001	<.001	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

eIF4E by AMACR expression — UCEC

Explore this box plot interactively →