AMACR

Across TCGA cell cohorts, AMACR RNA expression is significantly associated with the go_rna of many other GO terms, with 3,483 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AMACR-associated GO terms across cancer lineages are Fatty acid beta-oxidation, Monocarboxylic acid catabolic process, and Fatty acid catabolic process. Each is linked with AMACR in more than 12 cancer types. Because this analysis shows association rather than direction, both AMACR-to-partner and partner-to-AMACR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Fatty acid beta-oxidation grouped by AMACR-low versus AMACR-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (AMACR→partner) and Y-score (partner→AMACR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Fatty acid beta-oxidation →	+0.100	+1.407	<.001	.002	3	12
KIDNEY	Monocarboxylic acid catabolic process →	+0.084	+2.407	<.001	<.001	3	12
URINARY_TRACT	Fatty acid catabolic process →	+0.092	+1.597	<.001	.001	2	13
UPPER_AERODIGESTIVE_TRACT	Fatty acid oxidation →	+0.070	+0.839	<.001	.001	2	13
UPPER_AERODIGESTIVE_TRACT	Fatty acid beta-oxidation using acyl-CoA oxidase →	+0.130	+0.894	.001	.002	3	11
UPPER_AERODIGESTIVE_TRACT	Lipid oxidation →	+0.070	+0.742	<.001	.005	2	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,483 associations by consensus.

Fatty acid beta-oxidation by AMACR expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →