AMACR

Across TCGA cell cohorts, AMACR mutation is significantly associated with the mutation status of many other genes, with 1,878 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible AMACR-associated genes across cancer lineages are SORBS1, SF3A1, and PCDHGA11. Each is linked with AMACR in more than 1 cancer types. Because this analysis shows association rather than direction, both AMACR-to-partner and partner-to-AMACR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SORBS1 grouped by AMACR-low versus AMACR-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (AMACR→partner) and Y-score (partner→AMACR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SORBS1 →	+2.043	+3.693	.009	.009	1	2
LARGE_INTESTINE	SF3A1 →	+3.159	+4.632	<.001	<.001	1	2
LARGE_INTESTINE	PCDHGA11 →	+2.159	+3.807	.007	.007	1	2
LARGE_INTESTINE	PGM1 →	+4.329	+4.329	.001	.001	1	2
LARGE_INTESTINE	SLC35C2 →	+3.744	+5.000	<.001	<.001	1	2
LARGE_INTESTINE	ATP8B1 →	+2.422	+4.050	.004	.004	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,878 associations by consensus.

SORBS1 by AMACR expression — LARGE_INTESTINE

Explore this box plot interactively →