Across TCGA patient cohorts, ALYREF protein abundance is significantly associated with the RNA expression of many other genes, with 17,213 significant associations in total. GBM shows the largest number of these associations.

The most reproducible ALYREF-associated genes across cancer lineages are CTSG, CXCR1, and CFD. Each is linked with ALYREF in more than 7 cancer types. Because this analysis shows association rather than direction, both ALYREF-to-partner and partner-to-ALYREF results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ALYREF→partner) and Y-score (partner→ALYREF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CTSG →	-1.283	-0.350	<.001	<.001	3	8
LSCC	CXCR1 →	-0.936	-0.347	<.001	<.001	3	7
GBM	CFD →	-1.395	-0.307	<.001	<.001	3	7
GBM	MRC1 →	-1.776	-0.288	<.001	.001	3	7
GBM	UCHL5 →	+0.471	+0.328	<.001	.001	3	6
UCEC	TEK →	-0.703	-0.191	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,213 associations by consensus.

Exploration

ALYREF survival (RNA) · tumor vs normal (RNA) · all ALYREF data types